Allou, L., Balzano, S., Magg, A., Quinodoz, M., Royer-Bertrand, B., Schöpflin, R., Chan, W., Speck-Martins, C.E., Carvalho, D.R., Farage, L., et al. …. Grote, P., Rivolta, C., Mundlos S and Superti-Furga Andrea (2021). Non-coding deletions identify Maenli lncRNA as a limb-specific En1 regulator. Nature 592, 93–98.


Ali T, Grote P. 2020. Beyond the RNA-dependent function of LncRNA genes. Elife 9. doi:10.7554/eLife.60583

Rieke, J.M., Zhang, R., Braun, D., Yilmaz, Ö., Japp, A.S., Lopes, F.M., Pleschka, M., Hilger, A.C., Schneider, S., Newman, W.G., ··· , Grote, P., Zwink, N., Jenetzky, E., Brusco, A., Thiele, H., Ludwig, M., Schweizer, U., Woolf, A.S., Odermatt, B. and Reutter, H. (2020). SLC20A1 Is Involved in Urinary Tract and Urorectal Development. Front. Cell Dev. Biol. 8, 1–16.

Zhang, R., Gehlen, J., Kawalia, A., Melissari, M.T., Dakal, T.C., Menon, A.M., Höfele, J., Riedhammer, K., Waffenschmidt, L., Fabian, J., ., ··· , Grote, P., Schumacher, J., Thiele, H., Reutter, H. (2020). Human exome and mouse embryonic expression data implicate ZFHX3, TRPS1, and CHD7 in human esophageal atresia. PLoS One 15, 1–14.


Ritter, N.*, Ali, T.*, Kopitchinski, N., Schuster, P., Beisaw, A., Hendrix, D.A., Schulz, M.H., Müller-McNicoll, M., Dimmeler, S., and Grote, P. (2019). The lncRNA Locus Handsdown Regulates Cardiac Gene Programs and Is Essential for Early Mouse Development. Dev. Cell 50, 644-657.e8.

Fischer, C., Metsger, M., Bauch, S., Vidal, R., Böttcher, M., Grote, P., Kliem, M., and Sauer, S. (2019). Signals trigger state-specific transcriptional programs to support diversity and homeostasis in immune cells. Sci. Signal. 12, eaao5820.

Kolvenbach, C.M., Dworschak, G.C., Frese, S., Japp, A.S., Schuster, P., Wenzlitschke, N., Yilmaz, Ö., Lopes, F.M., Pryalukhin, A., Schierbaum, L., . . . Grote, P., Zaniew, M., Odermatt, B. and Hilger, A. (2019). Rare Variants in BNC2 Are Implicated in Autosomal-Dominant Congenital Lower Urinary-Tract Obstruction. Am. J. Hum. Genet. 104, 994–1006.

Mirtschink, P., Bischof, C., Pham, M.-D., Sharma, R., Khadayate, S., Rossi, G., Fankhauser, N., Traub, S., Sossalla, S., Hagag, E., Berthonneche, C., Sarre, A., Stehr, S.N., Grote, P., Pedrazzini, T., Dimmeler, S., Krek, W and Krishnan, J. (2019). Inhibition of the HIF1α-Induced Cardiospecific HERNA1 eRNA Protects from Heart Disease. Circulation. 139, 2778–2792.


Grote, P., and Boon, R.A. (2018). LncRNAs Coming of Age. Circ. Res. 123, 535–537.

Neumann, P., Jaé, N., Knau, A., Glaser, S.F., Fouani, Y., Rossbach, O., Krüger, M., John, D., Bindereif, A., Grote, P., et al. (2018). The lncRNA GATA6-AS epigenetically regulates endothelial gene expression via interaction with LOXL2. Nat. Commun. 9, 237.


Beisaw, A., Tsaytler, P., Koch, F., Schmitz, S.U., Melissari, M.-T., Senft, A.D., Wittler, L., Pennimpede, T., Macura, K., Herrmann, B.G. and Grote, P. (2017). BRACHYURY directs histone acetylation to target loci during mesoderm development. EMBO Rep. 19, e201744201.

Koch, F., Scholze, M., Wittler, L., Schifferl, D., Sudheer, S., Grote, P., Timmermann, B., Macura, K., and Herrmann, B.G. (2017). Antagonistic Activities of Sox2 and Brachyury Control the Fate Choice of Neuro-Mesodermal Progenitors. Dev. Cell 42, 514–526.e7.

Bischoff, F.C., Werner, A., John, D., Boeckel, J.-N., Melissari, M.-T., Grote, P., Glaser, S.F., Demolli, S., Uchida, S., Michalik, K.M., et al. (2017). Identification and Functional Characterization of Hypoxia-Induced Endoplasmic Reticulum Stress Regulating lncRNA (HypERlnc) in Pericytes. Circ. Res. 121, 368–375.


Sudheer, S., Liu, J., Marks, M., Koch, F., Anurin, A., Scholze, M., Senft, A.D., Wittler, L., Macura, K., Grote, P., et al. (2016). Different Concentrations of FGF Ligands, FGF2 or FGF8 Determine Distinct States of WNT-Induced Presomitic Mesoderm. Stem Cells 34, 1790–1800.

Schmitz, S.U., Grote, P., and Herrmann, B.G. (2016). Mechanisms of long noncoding RNA function in development and disease. Cell. Mol. Life Sci. 73, 2491–2509.

Melissari, M.-T., and Grote, P. (2016). Roles for long non-coding RNAs in physiology and disease. Pflugers Arch. 468, 945–958.


Marks, M., Pennimpede, T., Lange, L., Grote, P., Herrmann, B. G., & Wittler, L. (2015). Analysis of the Fam181 gene family during mouse development reveals distinct strain-specific expression patterns, suggesting a role in nervous system development and function. Gene. doi:10.1016/j.gene.2015.09.035

Grote, P., & Herrmann, B. G. (2015). Long noncoding RNAs in organogenesis: making the difference. Trends in Genetics, 1–7.


Schwartz, B., Marks, M., Wittler, L., Werber, M., Währisch, S., Nordheim, A., Herrmann B.G. and Grote, P. (2014). SRF is essential for mesodermal cell migration during elongation of the embryonic body axis. Mechanisms of Development, 133, 23–35.

Werber M, Wittler L, Timmermann B, Grote P*, Herrmann BG*. 2014. The tissue-specific transcriptomic landscape of the mid-gestational mouse embryo. Development 141:2325–30.* Corresponding authors


Grote P, Herrmann BG. (2013). The long non-coding RNA Fendrr links epigenetic control mechanisms to gene regulatory networks in mammalian embryogenesis. RNA Biol 10:1579–85.

Grote, P., Wittler, L., Hendrix, D., Koch, F., Währisch, S., Beisaw, A., Macura, K., Bläss, G., Kellis, M., Werber, M., et al. (2013). The tissue-specific lncRNA Fendrr is an essential regulator of heart and body wall development in the mouse. Dev Cell 24, 206–214. Faculty of 1000 – recommended article

Grimm C, Chavez L, Vilardell M, Farrall AL, Tierling S, Böhm JW, Grote P, Lienhard M, Dietrich J, Timmermann B, Walter J, Schweiger MR, Lehrach H, Herwig R, Herrmann BG, Morkel M. (2013). DNA-methylome analysis of mouse intestinal adenoma identifies a tumour-specific signature that is partly conserved in human colon cancer. PLoS Genet 9:e1003250.

2012 and older

Vidigal, J. a., Morkel, M., Wittler, L., Brouwer-Lehmitz, A., Grote, P., Macura, K., and Herrmann, B.G. (2010). An inducible RNA interference system for the functional dissection of mouse embryogenesis. Nucleic Acids Res. 38, e122.

Wittler, L., Shin, E.H., Grote, P., Kispert, A., Beckers, A., Gossler, A., Werber, M., and Herrmann, B.G. (2007). Expression of Msgn1 in the presomitic mesoderm is controlled by synergism of WNT signalling and Tbx6. EMBO Rep 8, 784–789.

Grote, P., and Conradt, B. (2006). The PLZF-like protein TRA-4 cooperates with the Gli-like transcription factor TRA-1 to promote female development in C. elegans. Dev Cell 11, 561–573. Faculty of 1000 – recommended article

Gil N, Ulitsky I. 2020. Regulation of gene expression by cis-acting long non-coding RNAs. Nat Rev Genet 21:102–117. doi:10.1038/s41576-019-0184-5

Biochimica et Biophysica Acta (BBA) – Gene Regulatory Mechanisms, Volume 1859, Issue 1 (January 2016), Special issue: Clues to long noncoding RNA taxonomy

Bassett, A.R., Akhtar, A., Barlow, D.P., Bird, A.P., Brockdorff, N., Duboule, D., Ephrussi, A., Ferguson-Smith, A.C., Gingeras, T.R., Haerty, W., Higgs, D.R., MIska, E.A. and Ponting C.P. (2014). Considerations when investigating lncRNA function in vivo. Elife 3, e03058.

Fatica, A., and Bozzoni, I. (2013). Long non-coding RNAs: new players in cell differentiation and development. Nat. Rev. Genet. 15, 7–21.

Ulitsky, I., and Bartel, D.P. (2013). lincRNAs: genomics, evolution, and mechanisms. Cell 154, 26–46.

Rinn, J.L., and Chang, H.Y. (2012). Genome regulation by long noncoding RNAs. Annu. Rev. Biochem. 81, 145–166.